ACETYLATOR PHENOTYPE AND THE CLINICAL PHARMACOLOGY OF SLOW-RELEASE PROCAINAMIDE
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چکیده
منابع مشابه
The association of the slow acetylator phenotype with bladder cancer.
There is an association between exposure to aromatic amines and the development of bladder cancer. Aromatic amines such as are known to occur in tobacco smoke are polymorphically acetylated. One hundred bladder cancer patients have been acetylator phenotyped. Only three of them were non-smokers at the time of diagnosis. This new series, together with four previous series (each with its own cont...
متن کاملAn improved and simplified method of detecting the acetylator phenotype.
A genetic polymorphism has been shown in man for the metabolism of isoniazid (Knight, Selin, and Harris, 1959; Evans, Manley, and McKusick, 1960; Sunahara et al., 1963a, b), and has been shown to control acetylation (Evans, 1962; Jenne, 1963; Evans and White, 1964; Peters, Miller, and Brown, 1965). The acetylation of sulphadimidine (sulfamethazine) has been found to be under the same genetic co...
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SUMMY A 71-year-old man with paroxysmal atrial fibrillation who had a previous anterior myocardial infarction exhibited granulocytopenia 8 days following the administration of oral sustained-release procainamide (750mg/day). The plasma concentrations of procainamide and N-acetyl procainamide were at subtherapeutic levels. Discontinuation of procainamide led to complete recovery. A bone marrow a...
متن کاملThe use of the autoanalyzer to determine the acetylator phenotype.
It has been pointed out (Rao et al, 1970) that with the advent of intermittent treatment regimens the determination of the acetylator phenotype has become of practical importance. It has recently been shown that rapid acetylators have an inferior response to slow acetylators when their tuberculosis is treated with once weekly treatment regimens (Menon, 1968; Tuberculosis Chemotherapy Centre, Ma...
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Introduction: The present study was conducted with the aim of determining the relationship between the components of clinical pharmacology curriculum and clinical skills of nursing students. Methods: The statistical population of this descriptive cross-sectional study includes nursing students of the Bandar Abbas School of Midwifery Nursing. Samples were collected by census. The data based on ...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1976
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1976.tb00352.x